Our hero is ready for action. Duke must escape his alien prison cell, then battle to end the hideous plans of the Rigelatins.

For fans of the original Duke Nukem, your favorite touches return: soda cans for health, turkey for food, spy cameras watching your every move, boxes you can destroy for bonuses and surprises, and more. Duke still flips, and he walks hand over hand across pipes, chains and ropes, with the new ability of shooting downward while doing so. Duke can also crouch, duck, and shoot upward.

Duke has four weapons: blaster, laser cannon, missiles, and flame thrower. The flame thrower, when aimed downward, propels Duke upward like a jetpack!